StressCovidV1, Main, Exploration, bibRecord, 000849

TEX264 is a major receptor for mammalian reticulophagy.

Identifieur interne : 000849 ( Main/Exploration ); précédent : 000848; suivant : 000850

TEX264 is a major receptor for mammalian reticulophagy.

Auteurs : Elizabeth Delorme-Axford [États-Unis] ; Hana Popelka [États-Unis] ; Daniel J. Klionsky [États-Unis]

Source :

Autophagy [ 1554-8635 ] ; 2019.

RBID : pubmed:31362563

Descripteurs français

KwdFr :
- Animaux, Autophagie, Protéines de tissu nerveux, Protéines de transport, Protéines du cycle cellulaire, Réticulum endoplasmique, Souris, Stress du réticulum endoplasmique.
MESH :
- Animaux, Autophagie, Protéines de tissu nerveux, Protéines de transport, Protéines du cycle cellulaire, Réticulum endoplasmique, Souris, Stress du réticulum endoplasmique.

English descriptors

KwdEn :
- Animals, Autophagy, Carrier Proteins, Cell Cycle Proteins, Endoplasmic Reticulum, Endoplasmic Reticulum Stress, Mice, Nerve Tissue Proteins, Nutrients.
MESH :
- chemical : Carrier Proteins, Cell Cycle Proteins, Nerve Tissue Proteins.
- Animals, Autophagy, Endoplasmic Reticulum, Endoplasmic Reticulum Stress, Mice, Nutrients.

Abstract

The endoplasmic reticulum (ER) is the main site of cellular protein and calcium homeostasis, as well as lipid synthesis in eukaryotic cells. Reticulophagy is the selective clearance and degradation of ER components and membranes by the cellular autophagy machinery. Recently, 2 groups (the laboratories of Noboru Mizushima and Wade Harper) independently identified the previously uncharacterized protein TEX264 (testis expressed gene 264) as a major receptor for selective reticulophagy in mammalian cells. Here we highlight and integrate the major findings of their recent work. Abbreviations: AIM: Atg8-interacting motif; AP-MS: affinity purification-mass spectrometry; ATL3: atlastin GTPase 3; Baf A₁: bafilomycin A₁; CCPG1: cell cycle progression 1; CRISPR: clustered regularly interspaced short palindromic repeats; GABARAP: gamma-aminobutyric acid receptor associated protein; GFP: green fluorescent protein; GyrI: gyrase inhibitor; IDR: intrinsically disordered region; IP: immunoprecipitation; KO: knockout; LIR: LC3-interacting region; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MEF: mouse embryonic fibroblast; MS: mass spectrometry; MTOR: mechanistic target of rapamycin kinase; RB1CC1/FIP200: RB1-inducible coiled-coil 1; RFP: red fluorescent protein; RNAi: RNA interference; RTN3: reticulon 3; RTN3L: long isoform of RTN3; siRNA: small interfering RNA; SARS: selective autophagy receptors; ss: signal sequence; TEM: transmission electron microscopy, TEX264: testis expressed gene 264; TMT: tandem mass tagging.

DOI: 10.1080/15548627.2019.1646540
PubMed: 31362563

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">The endoplasmic reticulum (ER) is the main site of cellular protein and calcium homeostasis, as well as lipid synthesis in eukaryotic cells. Reticulophagy is the selective clearance and degradation of ER components and membranes by the cellular autophagy machinery. Recently, 2 groups (the laboratories of Noboru Mizushima and Wade Harper) independently identified the previously uncharacterized protein TEX264 (testis expressed gene 264) as a major receptor for selective reticulophagy in mammalian cells. Here we highlight and integrate the major findings of their recent work. <b>Abbreviations:</b>
 AIM: Atg8-interacting motif; AP-MS: affinity purification-mass spectrometry; ATL3: atlastin GTPase 3; Baf A<sub>1</sub>
: bafilomycin A<sub>1</sub>
; CCPG1: cell cycle progression 1; CRISPR: clustered regularly interspaced short palindromic repeats; GABARAP: gamma-aminobutyric acid receptor associated protein; GFP: green fluorescent protein; GyrI: gyrase inhibitor; IDR: intrinsically disordered region; IP: immunoprecipitation; KO: knockout; LIR: LC3-interacting region; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MEF: mouse embryonic fibroblast; MS: mass spectrometry; MTOR: mechanistic target of rapamycin kinase; RB1CC1/FIP200: RB1-inducible coiled-coil 1; RFP: red fluorescent protein; RNAi: RNA interference; RTN3: reticulon 3; RTN3L: long isoform of RTN3; siRNA: small interfering RNA; SARS: selective autophagy receptors; ss: signal sequence; TEM: transmission electron microscopy, TEX264: testis expressed gene 264; TMT: tandem mass tagging.</div>
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TEX264 is a major receptor for mammalian reticulophagy.

TEX264 is a major receptor for mammalian reticulophagy.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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